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Mood Alteration and Rewarding Properties of Opioids (Pain Part 7)

Duration: 39:06

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2 Comments

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kakavand@*.com

Jan 31 2024, 7:10 pm

Excellent lecture, and explanation.!

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mobeen@*.com

Jan 31 2024, 7:45 pm

Thank you!

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kakavand@*.com

Jan 31 2024, 7:45 pm

where are the online lectures/and videoes? I was hoping to take the test/survey and get cme

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kakavand@*.com

Jan 31 2024, 7:09 pm

Please send CME. Thank you.

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mobeen@*.com

Jan 31 2024, 7:45 pm

CME questions are in progress. Will be on soon.

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kakavand@*.com

Jan 31 2024, 7:45 pm

thank you :)

In this talk we will discuss the following topics:
1. Difference between reward and reinforcement behavior.
2. Role of dopamine release for reward and the nuanced effects of opioids.
3. Mesolimbic dopamine pathway.
4. Ventral tegmental area (VTA) and its connections to nucleus accumbens and other neuronal tissues.
5. Review of a study discussing the role of dopamine under opioid influence.
6. Locations of opioid receptors in the mesolimbic pathway.
7. Neuronal circuitry for rewarding behavior and the effect of opioids on this circuit.
8. Neuronal circuitry for reinforcement behavior and the effect of opioids on this circuit.
9. Role of pain in reinforcement behavior.

Mood Alterations and Rewarding Properties

Brunton, Laurence; Knollman, Bjorn; Hilal-Dandan, Randa. Goodman and Gilman's The Pharmacological Basis of Therapeutics, 13th Edition (Goodman and Gilman"S the Pharmacological Basis of Therapeutics) (p. 1376). McGraw Hill LLC. Kindle Edition.

Ventral pallidum cellular and pathway specificity in drug-seeking - ScienceDirect
https://www.sciencedirect.com/science/article/abs/pii/S0149763421003894

Ventral Pallidum - an overview | ScienceDirect Topics
https://www.sciencedirect.com/topics/neuroscience/ventral-pallidum

Mesolimbic dopamine signaling in acute and chronic pain: imp...: PAIN
https://journals.lww.com/pain/fulltext/2016/06000/mesolimbic_dopamine_signaling_in_acute_and_chronic.4.aspx#:~:text=Research%20shows%20that%20the%20ability,reduced%20responsiveness%20to%20appetitive%20stimuli.

Mesolimbic pathway - Wikipedia
https://en.wikipedia.org/wiki/Mesolimbic_pathway

https://www.jstage.jst.go.jp/article/josnusd/59/2/59_16-0874/_pdf#:~:text=Opioids%20are%20thought%20to%20enhance,in%20the%20ventral%20tegmental%20area.

  • * Assess opioid effects on the mesolimbic-dopamine circuit.
  • * Explore opioid modulation of the GABA inhibitory system in the mesolimbic pathway.
  • * Differentiate between opioid-induced hedonic experiences and reinforcement mechanisms.
  • * Analyze the traditional reward circuit and the neurobiological basis of opioid reinforcement.
  • * Recognize the precise mechanisms influencing dopaminergic pathways in normal and opioid-influenced states

Following answers are created by ChatGPT. Occasionally the answer may be harmful, incorrect, false, misleading, incomplete, or limited in knowledge of world. Please contact your doctor for all healthcare decisions. Also, double check the answer provided by the AI below.

Faculty

In addition to the presenter, following authors may have helped with the content writing, review, or approval:

  • Dr. Mobeen Syed

CME, CE, CEU and Other Credit Types:

ACCME Accreditation Statement
The DrBeen Corp is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

AMA Credit Designation Statement
The DrBeen Corp designates this enduring material for a maximum of 0.75 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.


Disclosure Information

In accordance with the disclosure policies of DrBeen Corp and the ACCME (Accreditation Council for Continuing Medical Education), we are committed to upholding principles of balance, independence, objectivity, and scientific rigor in all of our Continuing Medical Education (CME) and Continuing Education (CE) activities. These policies include the careful management and mitigation of any relevant financial relationships with organizations that are not eligible.
All members of the Activity Planning Committee and presenters have disclosed their relevant financial relationships. The DrBeen Corp CE Committee has thoroughly reviewed these disclosures and determined that these relationships are not deemed inappropriate in the context of their respective presentations. Additionally, they are found to be consistent with the educational objectives and the integrity of the activity.

Faculty Disclosures
Dr. Mobeen Syed Author declares no conflict of interest.

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